Yorkie drives Ras-induced tumor progression by microRNA-mediated inhibition of cellular senescence
Although activating mutations in the GTPase Ras promote cancer, Ras also induces cellular senescence, a barrier that is necessary to overcome for Ras activation to promote tumor progression. Using a model of Ras-induced tumor growth in flies, Ito and Igaki found that Ras-induced cellular senescence required the ETS family transcription factor Pnt. Loss of cell […]
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